ATR prevents premature apoptosis

Nuclear Chk1 prevents premature mitotic entry.

Chk1 inhibits the premature activation of the cyclin-B1-Cdk1. However, it remains controversial whether Chk1 inhibits Cdk1 in the centrosome or in the nucleus before the G2-M transition. In this study, we examined the specificity of the mouse monoclonal anti-Chk1 antibody DCS-310, with which the centrosome was stained. Conditional Chk1 knockout in mouse embryonic fibroblasts reduced nuclear but...

Olfactory stimulation prevents apnea in premature newborns.

OBJECTIVE Methylxanthines and doxapram are currently used to treat apnea of prematurity but are not fully effective and often present undesirable side effects. The present study examines whether exposure to an odor known to modulate the infant's respiratory rate could reduce the frequency of apneic spells. METHOD Fourteen preterm newborns born at 24 to 28 gestational weeks presenting recurren...

Apoptosis prevents osteoporosis

Apoptosis prevents osteoporosis G randmothers everywhere know well that estrogen defi cits lead to osteoporosis. Now, the molecular basis for this debilitating bone loss is fi nally identifi ed. Estrogen is needed to kill off bone-destroying osteoclasts, show Takashi Nakamura, Shigeaki Kato (University of Tokyo, Japan), and colleagues. The root cause of osteoporosis has been diffi cult to pin d...

Linomide Prevents Apoptosis in Hepatocytes

Fas is an apoptosis-signaling receptor molecule expressed in vivo on thymocytes, liver, heart, and ovary. In vivo administration of the anti-Fas Jo2 antibody in mice induces severe apoptotic liver damage leading to fulminant hepatitis and death. Linomide, a quinoline 3-carboxamide, inhibits apoptosis of B and T cells induced by various stimuli including viruses, superantigens, and glucocorticoi...

donepezile prevents morphine-induced apoptosis in rat cerebral cortex